Hyperbaric oxygen therapy (HBOT) is sometimes used to treat fistulas. Has anyone considered rectal insufflation ozone therapy for anal fistulas, rather than traditional HBOT? This small study concluded this treatment is not promising. However, even with such a low success rate (25%), I wonder if this therapy may be worth a try since it is relatively painless and low risk. I imagine it would be cost prohibitive for most patients since insurance would most likely not cover ozone therapy.
https://link.springer.com/article/10.1007/s12262-016-1475-0
